- Carnitine metabolism affects the normal functioning of the whole body, and plays a major role in both lipid and glucose metabolism.
- L-carnitine deficiency has been observed in inborn errors of metabolism as well as in infertility, pregnancy, intrauterine growth restriction, premature neonates, liver disease, and in xenobiotics (valproate) evoked toxicity.
- Extensive preclinical and clinical research studies have confirmed the positive role that L-carnitine treatment can have not only in the conditions mentioned above but also in other disease states like myalgic encephalomyelitis/chronic fatigue syndrome, neurodegenerative conditions, and diabetes.
- New recent research is beginning to show that L-carnitine can also modulate gene expression and other critical biological processes in addition to its key role in mitochondrial energy metabolism.
- This series of monographs together with slide presentations and educational videos review the most recent scientific and clinical evidence on the beneficial role of L-carnitine in the management of various medical conditions including fertility and reproduction, fatty liver disease, and valproate induced secondary carnitine deficiency.
- This section also includes expert interviews which address current challenges in managing endocrine and metabolic disorders with L-carnitine supplementation.
ENDOCRINE AND METABOLIC DISORDERS